Step 2. Right-click the game entry and select Properties. Step 1. Open the Steam client, and then navigate to the Library tab and locate The Binding of Isaac from the list of games. Here we will show you how to disable overlay in Discord and Steam separately. We don’t know why the Overlay feature can cause the error, but it’s worth having a try. Many gamers reported that they fixed the Binding of Isaac not responding simply by disabling the Overlay feature.
To resolve it, we summarize the following effective fixes after analyzing extensive user reports on forums and communities.